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(2002) Prevalence and risk fac-tors of silent brain infarcts in the population-based RotterdamScan Study. The first is with LAG-3 activation in T cells where itwas mention that LAG activation negatively affects early T cell activation events (Macon-Lemaitre 2005) buy modafinil uk 2018 but also it was determined that LAG engagement by MHC-class II caninduce down regulated T cell proliferation to the point where the level of T cell activity isbelow normal homeostatic conditions (Workman 2005). These observations claim that depending on the presence of muta-tions on TP53 different clinical outcomes may be expected in patients treated withtherapies based on p53 activation, with deleterious consequences in cases express-ing p53 point mutants.
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