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Buttitta F Marchetti A, Gadducci A, Pellegrini S, Morganti M, Carnicelli V, Cosio S, GagettiO, Genazzani AR, Bevilacqua G (1997) p53 alterations are predictive of chemoresistance andaggressiveness in ovarian carcinomas: a molecular and immunohistochemical study.
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As a consequence of the body having only alimited number of P450s with which to oxidatively metabo-lize hundreds of drugs and xenobiotics, when inhibitoryinteractions do occur, the mechanism is often simple compe-tition for limited amounts of enzyme (Figure 2.9a).
However, the formation of a stablecomplex between Ku and DNA-PK requires conformational changes in Ku whichoccur only in the presence of DNA ends , and promote the interaction of Kuwith DNA polymerases ? and ?, and with the XRCC4-DNA ligase IV complex .Interaction between two such complexes on two DNA ends tethers the ends andtriggers the kinase activity of DNA-PK which then phosphorylates various repairproteins.
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